Metatarsalgia, pain in the metatarsal/forefoot area, is a common foot problem. In milder cases, it can be managed with pads, supportive footwear, adequate rest, NIAIDs, and other remedies. However, some cases become more severe over time. They cause considerable pain and undermine mobility. Among the treatments that help manage the syndrome, prolotherapy has won a number of adherents. It involves injections of dextrose, often mixed with an anesthetic. The injections stimulate natural healing. But prolotherapy is not necessarily the best option.