The Afghan Herbal Medicines for Addiction and Depression project aims to conduct clinical trials of promising herbal medicines drawn from Afghanistan’s high-potential medicinal and aromatic plants (MAP) sector, in keeping with traditional Unani medicine. Addiction (overwhelmingly from opiates) and depression (some from Post-Traumatic Stress Disorder from the horrors of Afghanistan’s wars, and some from mistreatment of women) represent especially salient targets, and they possess worldwide importance. Unani herbal medicines have been reported in preliminary Iranian clinical studies to be effective and safe in these indications, and they possess certain advantages over synthetic drugs. However, thorough, scientific, multicenter trials need to be done.